Amikacin, Trough
Also known as: Amikin®
Use
Amikacin is used to treat serious infections caused by susceptible aerobic gram-negative bacilli (e.g., a number of the Enterobacteriaceae, P. aeruginosa). Such infections include bacteremias; intra-abdominal, soft tissue (including burns), bone or joint, lower respiratory tract and complicated urinary tract infections, and meningitis.
Special Instructions
Peak levels should be ordered using Test No. 007204. Trough levels should be ordered using Test No. 007205. Please label tubes appropriately as 'peak' and 'trough.'
Limitations
Nephrotoxicity occurs in 10-25% of patients using aminoglycosides, with trough levels >8 μg/mL linked to renal damage. The risk of ototoxicity is less clear, with monitoring and dosing adjustments reducing auditory toxicity correlations. Stability issues arise with gel-barrier tubes due to drug absorption, leading to potentially significant clinical impact.
Methodology
Immunoassay (IA)
Biomarkers
LOINC Codes
- 3321-7
- 3321-7
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or green-top (heparin) tube. Do not use a gel-barrier tube.
Collection Instructions
Transfer separated serum or plasma to a plastic transport tube. The trough sample is drawn immediately prior to the next dose.
Storage Instructions
Room temperature
Causes for Rejection
Gel-barrier tube; severe hemolysis; lipemia; icteric specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |