Amikacin, Trough
Also known as: Amikin®
Use
Amikacin is used to treat serious infections caused by susceptible aerobic gram-negative bacilli (e.g., a number of the Enterobacteriaceae, P. aeruginosa). Such infections include bacteremias; intra-abdominal, soft tissue (including burns), bone or joint, lower respiratory tract and complicated urinary tract infections, and meningitis.
Special Instructions
Not provided.
Limitations
Nephrotoxicity occurs in 10-25% of patients using aminoglycosides, with trough levels >8 μg/mL linked to renal damage. The risk of ototoxicity is less clear, with monitoring and dosing adjustments reducing auditory toxicity correlations. Stability issues arise with gel-barrier tubes due to drug absorption, leading to potentially significant clinical impact.
Methodology
Immunoassay (IA)
Biomarkers
Amikacin
Analyte
LOINC Codes
- 3321-7 - Amikacin Trough SerPl-mCnc
- 3321-7 - Amikacin Trough SerPl-mCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or green-top (heparin) tube. Do not use a gel-barrier tube.
Collection Instructions
Transfer separated serum or plasma to a plastic transport tube. The trough sample is drawn immediately prior to the next dose.
Storage Instructions
Room temperature
Causes for Rejection
Gel-barrier tube; severe hemolysis; lipemia; icteric specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant