Anal (Rectal) Cytology, Liquid-based Preparation
Also known as: Anal Pap (LBP)
Use
Diagnose primary and metastatic malignant neoplasms; differential diagnosis of benign versus malignant processes.
Special Instructions
The test involves collecting an anal-rectal cytology (ARC) specimen using a swab. The swab is moistened in tap water and inserted into the anal canal with gentle rotation and pressure to obtain a representative sample from the transition zone. The swab is then vigorously rotated in a preservative solution to ensure adequate release of cellular material for analysis.
Limitations
The test may not detect all cases of anal or rectal neoplasia due to sampling limitations. Additionally, specimens more than 21 days old, improperly labeled, or submitted in expired or frozen conditions could be rejected. The test may also require additional confirmatory or reflex tests, which can affect the turnaround time for final results.
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 47526-9
- 22633-2
- 52797-8
- 47526-9
- 22638-1
- 22636-5
- 22634-0
- 22635-7
- 11546-9
- 19139-5
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Other
Volume
1-2 mL
Minimum Volume
Not provided
Container
Vial with PreservCyt® solution, ThinPrep® vial; vial with CytoRich™ fixative, SurePath™ vial
Collection Instructions
An anal-rectal cytology specimen is collected using a swab, rotated in PreservCyt® or CytoRich™ fixative solution, and then the swab is discarded. The vial must be tightly capped, properly labeled, and accompanied by a test request form indicating the source of the specimen.
Patient Preparation
No special preparation is needed, but patients should avoid receptive anal intercourse or use of intra-anal preparations before examination.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Improper labeling; specimen more than 21 days old; expired or frozen specimen.