Apixaban Anti-Xa
Use
To measure plasma apixaban concentration in ng/mL. Although routine monitoring is not needed, there are a number of clinical circumstances in which clinicians want or need to know a patient's apixaban level. Levels can be accurately and precisely measured using either a chromogenic anti-Xa assay or LC/MS-MS.
Special Instructions
This test was developed and its performance characteristics were determined by LabCorp. It has not been cleared or approved by the FDA.
Limitations
The assay is not specific for apixaban and will detect any direct or indirect factor Xa anticoagulant. Thus, while it can accurately determine apixaban concentration, it is not exclusive to apixaban and may be influenced by the presence of other Xa inhibitors. Furthermore, routine therapeutic monitoring is not required due to apixaban's wide therapeutic index, and measurements should only be considered in specific clinical situations.
Methodology
Other
Biomarkers
LOINC Codes
- 74214-8
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Blue-top (3.2% or 3.8% sodium citrate) tube
Collection Instructions
Separate plasma from cells by centrifugation. Transfer plasma to a plastic transport tube before freezing.
Storage Instructions
Freeze. Stable at room temperature for six hours. Freeze/thaw cycles: stable x6
Causes for Rejection
Gross hemolysis; gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 6 hours |
| Frozen | Stable through six freeze/thaw cycles |