Arsenic Exposure Profile, Urine
Also known as: As, Urine
Use
Monitor chronic exposure to arsenic
Special Instructions
A proper request form must state the volume collected if a 24-hour specimen is applicable. Do not use preservatives during sample collection as they can interfere with the results. Separate urine samples are required for urinalysis and metal testing to avoid interference. Patient preparation includes avoiding seafood for 72 hours prior to sample collection to prevent false elevation of arsenic levels.
Limitations
The test, developed by Labcorp, has not been FDA-approved, and its performance characteristics are based on Labcorp's determination. Acute arsenic exposure may be misrepresented if dietary sources are not considered. Seafood consumption can skew total arsenic levels, as nontoxic dietary forms include arsenobetaine and arsenocholine. The urine specimen provides a less transient measure of chronic exposure compared to blood.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 96253-0
- 2161-8
- 5586-3
- 13463-5
- 5587-1
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
5 mL
Minimum Volume
2.5 mL
Container
Plastic urine container, no preservative
Collection Instructions
Sampling time should coincide with the end of the workweek for industrial exposure assessment. Collect all urine within a 24-hour period if requested and avoid contact with metals during collection.
Patient Preparation
Avoid all seafood for 72 hours before collection, since seafood consumption can elevate arsenic levels in urine.
Storage Instructions
Maintain specimen at room temperature
Causes for Rejection
Highly dilute or highly concentrated specimens with creatinine concentrations not within acceptable limits of >0.30 g/L and <3.00 g/L.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |