C4 Complement (RDL)
Also known as: Complement Component 4
Use
Measurement of C4 in serum is used to detect individuals with inborn deficiency of this factor or those with immunologic disease in whom complement is consumed at an increased rate. These include lupus erythematosus, chronic active hepatitis, certain chronic infections, post-streptococcal and membranoproliferative glomerulonephritis, and others.
Special Instructions
This test is a component of ANA Profile 11, ANA Profile 12, ANA 12 Plus Profile, Vasculitis Profile.
Limitations
Room temperature specimens are stable for up to 2 days, refrigerated specimens for up to 8 days, and frozen specimens for up to 3 months. Stable for one freeze/thaw cycle. Specimens that are grossly hemolyzed, lipemic, icteric, or contaminated with bacteria are unsuitable for testing. The minimum volume requirement for testing (0.3 mL) does not allow for repeat testing.
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 4498-2
- 4498-2
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Gel tube or red-top tube
Collection Instructions
Separate serum from cells within one hour. Transfer to a plastic transport tube before freezing.
Storage Instructions
Store frozen or refrigerated.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic, icteric, non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 days |
| Refrigerated | 8 days |
| Frozen | 3 months |