Calcitonin (Thyrocalcitonin), Four Specimens
Use
Calcitonin is a hormone that is primarily produced by the C cells in the thyroid gland. It helps regulate calcium levels in the body and can be a valuable biomarker in the evaluation of patients with medullary thyroid carcinoma (MTC). This test is used to measure calcitonin levels across multiple time points to assess baseline and stimulated levels, which are crucial for diagnosing MTC as stimulated levels often exhibit a marked increase. This panel is part of a dynamic testing protocol used to better elucidate calcitonin levels under specific conditions, such as pharmacological stimulation, which provides insight into the patient's endocrine function and tumor activity.
Special Instructions
This test requires multiple specimens collected at different time points and involves administering a drug or treatment between collections. If treatment such as a pill, injection, or other stimulant is not planned, do not use this panel. Ensure to consult with the clinician for appropriate series ordering. Detailed instructions on multiple specimen testing are available in the Endocrine Appendix of the LabCorp Directory of Services.
Limitations
Different assay methods or kits cannot be used interchangeably for this test. Interpretation of results should consider that baseline calcitonin levels may vary and that specific conditions such as MTC influence stimulated results. Incorrect handling or deviation from required specimen collection procedures (e.g., timing after drug administration) can impact test accuracy. Ensure proper coordination when collecting samples and be aware that additional confirmatory tests might be necessary.
Methodology
Immunoassay (Immulite ICMA)
Biomarkers
LOINC Codes
- 58892-1
- 33788-1
- 12506-2
- 12507-0
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Container
Multiple tubes
Collection Instructions
Collect an initial tube (baseline), administer treatment, and collect subsequent tubes following treatment. Refer to specific time point requirements: Tube ID #1 - 0 Hour, Tube ID #2 - 1 Hour, Tube ID #3 - 2 Hour, Tube ID #4 - 3 Hour.
Patient Preparation
Ensure no treatment is administered if not specified for this panel. Coordinate with the clinician before series collection.