Ceruloplasmin
Use
Decreased in most instances of Wilson's disease (hepatolenticular degeneration); hence, ceruloplasmin is used in evaluation of chronic active hepatitis, cirrhosis, and other liver disease. In Wilson's disease, there is decreased ability to incorporate copper into apoceruloplasmin. As a result, free copper levels in plasma and in tissue, especially liver and brain, are greatly increased.
Special Instructions
Draw blood in a gel-barrier tube (preferred). Separate serum or plasma from cells within 45 minutes of collection. Transfer separated serum or plasma to a plastic transport tube.
Limitations
A normal ceruloplasmin level does not rule out Wilson's disease. Serum copper should be measured in addition for comprehensive evaluation of copper metabolism disorders.
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 2064-4
- 2064-4
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
Red-top tube, gel-barrier tube, or green-top (heparin) tube
Collection Instructions
Draw blood in gel-barrier tube (preferred). Separate serum or plasma from cells within 45 minutes of collection. Transfer separated serum or plasma to a plastic transport tube.
Storage Instructions
Refrigerate
Causes for Rejection
Hemolyzed specimen; specimen with improper identification
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |