Cobalt, Urine

Casandra

Casandra Test Code LC37929Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 071514CPT Codes 82570, 83018

Clinical Use

Order Test

Use

Monitor industrial exposure to cobalt

Special Instructions

Not provided.

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration. Urine specimens that are highly dilute or highly concentrated are generally not suitable for monitoring. The World Health Organization has guidelines for acceptable creatinine concentration limits: >0.30 g/L and <3.00 g/L.

Test Details

Methodology

Mass Spectrometry

Biomarkers

Cobalt

Analyte

Cobalt, Urine

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Cobalt/Creatinine Ratio

Analyte

Cobalt/Creatinine Ratio, Urine

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Creatinine

Analyte

Creatinine, Urine

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

13468-4 - Cobalt/Creat Ur
2161-8 - Creat Ur-mCnc
29916-4 - Cobalt 24h Ur-mRate
5628-3 - Cobalt Ur-mCnc

Result Codes

5628-3 - Cobalt Ur-mCnc
29916-4 - Cobalt 24h Ur-mRate
2161-8 - Creat Ur-mCnc
13468-4 - Cobalt/Creat Ur

Result Turnaround Time

2-4 days

Specimen

Urine

Volume

5 mL

Minimum Volume

1.5 mL

Container

Plastic urine container, no preservative

Collection Instructions

Sampling time is end of shift at end of work week. Metals with timing “end of shift at end of work week” (meaning four or five consecutive working days with exposure) are eliminated with half-lives longer than five hours. Such metals accumulate in the body during the work week; therefore, their timing is critical in relation to previous exposures. Optional protocol: Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Avoid contact with metal during collection. Screw the lid on securely.