Complement C4a

Casandra

Casandra Test Code LC44790Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 004330CPT Code 86160

Also known as: Complement C4a des-Arginine

Clinical Use

Order Test

Use

Activation of the complement system plays an important role in our natural ability to ward off infection and in the pathogenesis of infection and inflammation.1-6 Anaphylatoxins produced as the result of complement activation play a role in a number of infectious and inflammatory conditions including sepsis, ischemia-reperfusion injury, immune complex diseases, and hypersensitivity diseases like asthma.1 Anaphylatoxins are also thought to be important in the pathogenesis of allergy, autoimmunity, neurodegenerative diseases, and cancer.2,3

Special Instructions

Not provided.

Limitations

Results are intended for research purposes only by the assay's manufacturer, and performance characteristics have not been established. The test results should not be relied upon as a diagnostic procedure without further confirmation from a medically established diagnostic product. Elevation in C4a levels is not indicative of any specific disease and can occur in any inflammatory condition. Improper collection or storage of samples can result in erroneously elevated results due to in vitro activation.

Test Details

Methodology

Immunoassay (RIA)

Biomarkers

Complement C4a

Protein

Complement C4a

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

4501-3 - C4a Plas-mCnc

Result Codes

4501-3 - C4a Plas-mCnc

Result Turnaround Time

4-7 days

Specimen

Plasma

Volume

1 mL

Minimum Volume

0.5 mL

Container

Lavender-top (EDTA) tube

Collection Instructions

Collect EDTA whole blood sample into a chilled lavender-top tube. Immediately add Futhan preservative as directed in the Futhan collection kit. Recap lavender tube and invert several times to mix well. Centrifuge the whole blood specimen to separate the plasma. Transfer the plasma into the plastic screw-cap tube that is included in the collection kit. The specimen must be submitted in this transfer tube labeled 'Futhan Added.' Freeze immediately and maintain frozen until tested.