Cortisol, PM
Use
Cortisol is a steroid hormone produced by the adrenal glands. The measurement of cortisol levels at specific times during the day can provide valuable information about the functionality of the adrenal and pituitary glands. Cortisol levels typically fluctuate throughout the day, being highest in the morning and lowest at night. Monitoring the PM cortisol level can assist in diagnosing disorders such as Cushing's syndrome and Addison's disease, as well as evaluating appropriate corticosteroid therapy.
Special Instructions
State collection time and date on the specimen label. It is important to inquire about and recommend cessation of biotin (vitamin B7, vitamin H, or coenzyme R) supplementation at least 72 hours prior to sample collection to avoid potential interference with the test results.
Limitations
This test may show interference if the patient has taken biotin supplements. High doses of biotin can lead to inaccurate results, so patients should be advised to suspend biotin intake three days before sample collection.
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 9812-9
- 9812-9
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.7 mL
Container
Gel-barrier tube (preferred) or red-top tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Patient Preparation
Patients should stop biotin consumption at least 72 hours prior to sample collection.
Storage Instructions
Room temperature storage is acceptable.
Causes for Rejection
Citrate plasma specimen; improper labeling
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |