Cytochrome P450 2D6 Genotyping
Also known as: DME Genotyping
Use
Cytochrome P450 2D6 (CYP2D6) is a drug-metabolizing enzyme involved in the metabolism of more than 65 clinically important drugs including some antidepressants, anti-psychotics, opioids, beta-blockers, antiemetics, atomoxetine and tamoxifen. Individuals with some variant CYP2D6 alleles may experience a reduced therapeutic response and may be at risk for side effects from drugs that are metabolized by CYP2D6. CYP2D6 genotype information can be utilized to predict CYP2D6 metabolic phenotype, which can be used as an aid in determining a therapeutic strategy for drugs that are metabolized by CYP2D6. For example, CYP2D6 ultrarapid metabolizers may experience exaggerated side effects after the administration of codeine, while poor metabolizers may experience a reduced analgesic effect due to insufficient biotransformation into morphine. In these instances, alternative drugs may be considered.
Special Instructions
Not provided.
Limitations
The test does not detect all possible variants in the CYP2D6 gene or other drug metabolism pathways. Factors like environmental, dietary, and drug interactions can also influence metabolism. Rare diagnostic errors are possible despite high accuracy of molecular testing. The performance characteristics of this test were established by Labcorp, without FDA clearance or approval.
Methodology
PCR-based (RT-PCR)
Biomarkers
CYP2D6
GeneCYP2D6
Gene
LOINC Codes
- 72886-5 - CYP2D6+CYP2C19 pnl Bld/T
- 40425-1 - CYP2D6 allele Geno Bld/T
- 79715-9 - CYP2D6 gene prod met act imp Bld/T-Imp
- 72486-4 - Lab director name Provider
- 56850-1 - Imp & review of lab results
- 62364-5 - Test performance info Spec
- 8262-8 - Service Cmnt 02-Imp
Result Turnaround Time
7-10 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
2 mL
Minimum Volume
1 mL
Container
Lavender-top (EDTA) tube or yellow-top (ACD) tube
Collection Instructions
Collect specimen in a lavender-top (EDTA) or yellow-top (ACD) tube. Ship whole blood specimen at room temperature or frozen.
Storage Instructions
Maintain whole blood specimen at room temperature or refrigerated for 28 days or frozen for 2 years.
Causes for Rejection
Quantity not sufficient for analysis; improper container; frozen glass tube
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 28 days |
| Refrigerated | 28 days |
| Frozen | 2 years |
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