D-Dimer

Clinical Use

Use

The Innovance® D-dimer assay is intended for use in conjunction with a nonhigh clinical pretest probability (PTP) assessment model to exclude deep vein thrombosis (DVT) and pulmonary embolism (PE).6 This test can be used to exclude VTE with nonhigh pretest probability (ie, low or low/moderate pretest probability). In an exclusion strategy, a D-dimer below the established threshold in a nonhigh pretest probability patient does not require further testing to exclude VTE.

Special Instructions

Not provided.

Limitations

Results should be interpreted in conjunction with the patient's medical history, clinical presentation, and other findings. DVT clinical diagnosis should not be based solely on the Innovance® D-dimer result. D-dimer levels can be elevated due to a variety of clinical conditions, especially in hospitalized patients, and should not be used in pediatric patients for exclusion of venous thrombosis or pulmonary embolism. Several conditions like aortic aneurysm, trauma, surgery, disseminated malignancies, sepsis, and severe infections can increase D-dimer levels.

Test Details

Methodology

Immunoassay (Immunoturbidimetric assay)

Biomarkers

D-Dimer

Analyte

D-Dimer

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

48065-7 - D Dimer PPP FEU-mCnc

Result Codes

48065-7 - D Dimer PPP FEU-mCnc

Result Turnaround Time

1 day

Specimen

Plasma

Volume

2 mL

Minimum Volume

1 mL

Container

Blue-top (sodium citrate) tube

Collection Instructions

Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion for proper blood to anticoagulant ratio. Mix immediately by gentle inversion at least six times. A discard tube is not required before collection. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma, being careful not to disturb the cells. Deliver to a plastic transport tube, cap, and recentrifuge for 10 minutes. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap and freeze immediately.