Dehydroepiandrosterone (DHEA) Sulfate, Five Specimens
Use
Dehydroepiandrosterone sulfate (DHEA-S) is primarily produced in the adrenal cortex and is an important diagnostic marker for the assessment of adrenal gland function. Analyzing DHEA-S levels can help diagnose conditions related to adrenal gland disorders, such as adrenal tumors or adrenal hyperplasia, and investigate the androgen status in conditions such as hirsutism and polycystic ovary syndrome (PCOS). This test involves measuring the concentration of DHEA-S at multiple time points after a stimulant intervention, providing insights into the adrenal response.
Special Instructions
This test requires the collection of multiple specimens at different time points, adhering to a specific protocol post-stimulation with a drug or treatment. Before initiating the series, consult with a clinician if a treatment post-initial collection is not intended. Avoid biotin supplementation 72 hours before the test as it can interfere with results.
Limitations
Biotin supplementation can cause significant interference with DHEA-S test results, leading to inaccurate findings. Furthermore, testing schedules may vary, potentially affecting the consistency in timing across samples. Results may require contextual interpretation alongside additional tests for confirmatory or reflexive purposes.
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 56552-3
- 16723-9
- 16724-7
- 16725-4
- 16726-2
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Multiple tubes are to be drawn at specified intervals after a baseline collection and subsequent treatment administration.
Patient Preparation
Patients should avoid biotin supplementation 72 hours before specimen collection to prevent interference.