Digoxin, Serum
Also known as: Lanoxin®
Use
Diagnose and prevent digoxin toxicity; prevent underdosage; monitor therapeutic drug level; prevention and therapy of cardiac arrhythmias
Special Instructions
Ensure the patient is not on digitoxin. This test may exhibit interference when sample is collected from a person consuming a supplement with high doses of biotin. It is recommended to stop biotin consumption at least 72 hours prior to sample collection. Serum should be drawn six to eight hours after the last dose or just before the next dose if a steady-state estimate is needed, typically attained in five days.
Limitations
Digoxin should not be mistaken for digitoxin, and measurements may become unreliable in patients with renal failure due to endogenous digoxin-like substances. Quinidine can elevate digoxin levels by reducing its excretion. Various physiological and pathological conditions can affect sensitivity to digoxin and lead to toxicity, including renal failure, hypercalcemia, alkalosis, hypomagnesemia, and others. Cross-reactivity with digoxin-specific immunoassays can cause falsely elevated digoxin levels.
Methodology
Immunoassay (KIMS)
Biomarkers
LOINC Codes
- 10535-3
- 10535-3
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.7 mL
Container
Gel-barrier tube (preferred) or red-top tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube. Blood specimen must be drawn six to eight hours after the administration of the last dose. Collect specimen just before dose if steady-state estimate is needed.
Storage Instructions
Room temperature
Causes for Rejection
Citrate plasma specimen; improper labeling
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |