Edoxaban, Anti-Xa
Also known as: Savaysa®
Use
Measure plasma edoxaban concentration in ng/mL. Although routine monitoring is not needed, there are several clinical circumstances in which clinicians want or need to know a patient's edoxaban level. Levels can be accurately and precisely measured using either a chromogenic anti-Xa assay or LC/MS-MS.
Special Instructions
Collection involves separating plasma from cells by centrifugation before transferring the plasma to a plastic transport tube for freezing. Storage at room temperature for up to six hours is acceptable before freezing, with up to five freeze/thaw cycles permitted without compromising sample integrity.
Limitations
The assay is not specific exclusively to edoxaban; it will detect any factor Xa inhibitor, whether indirect or direct. This fact needs to be considered when interpreting results, particularly if the patient is on other factor Xa-inhibiting medications. Besides, interference in measurement can stem from various factors including lupus anticoagulants and heparin administration, although studies indicate that the laboratory's LC/MS-MS method is unaffected by such factors.
Methodology
Other
Biomarkers
LOINC Codes
- 80627-3
- 80627-3
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Blue-top (3.2% sodium citrate) tube
Collection Instructions
Separate plasma from cells by centrifugation. Transfer plasma to a plastic transport tube before freezing.
Storage Instructions
Freeze. Stable at room temperature for six hours. Freeze/thaw cycles: x5.
Causes for Rejection
Gross hemolysis; gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 6 hours |