Etanercept and Anti-Etanercept Antibody, DoseASSURE™ ETN
Also known as: Anti-TNF, DoseASSURE, Enbrel®
Use
Therapeutic monitoring of etanercept and antidrug antibody development for individuals with Crohn's disease, inflammatory bowel disease, ulcerative colitis, rheumatoid arthritis, or other autoimmune conditions. This test provides etanercept drug concentration as well as the level of anti-etanercept antibodies.
Special Instructions
Patients taking biotin supplements may need to discontinue use at least 72 hours before sample collection to avoid interference with the assay results. The test includes serial monitoring to track drug and antibody levels over time for better therapeutic management.
Limitations
The presence of anti-etanercept antibodies does not fully determine treatment efficacy; therapy failure may occur despite the absence of these antibodies. Additionally, high serum levels of biotin can cause assay interference, necessitating a pause in biotin supplementation before specimen collection for accurate results.
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 82470-6
- 82470-6
- 82469-8
Result Turnaround Time
6-12 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Serum-gel tube, red-top tube
Collection Instructions
Serum must be separated from cells within 45 minutes of venipuncture. Submit serum in a plastic transport tube. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Refrigerate or freeze. Stable at room temperature or frozen for 14 days. Freeze/thaw cycles: stable x6.
Causes for Rejection
Gross hemolysis; gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |