FLT3 Mutation Analysis
Also known as: FLT3 D835 mutation, FLT3 Internal Tandem Duplication and Tyrosine Kinase Domain mutation, FLT3 ITD and D835 mutations, FLT3 ITD and TKD mutations, FLT3 ITD mutation
Use
Mutations in the FLT3 gene are common mutations in acute myeloid leukemia (AML). This assay detects internal tandem duplication (ITD) mutations and mutations in the tyrosine kinase domain (TKD) of FLT3. Presence of these mutations in AML provide prognostic information and can aid in the determination of therapeutic regimen.
Special Instructions
Questions regarding this test can be directed to customer service at 800-345-4363.
Limitations
The PCR assay has a sensitivity capable of detecting a mutant cell population with a threshold as low as 5 mutant cells per 100. The test was developed by Labcorp and is managed for its performance characteristics but has not undergone clearance or approval by the Food and Drug Administration. Limitations include potential rejection if the specimen does not meet the collection criteria, is frozen, or presents issues such as clotting, hemolysis, contamination, or suspicious foreign material.
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 49549-9
- 72486-4
- 72520-0
- 75608-0
- 77202-0
- 79210-1
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3-5 mL
Minimum Volume
3 mL
Container
Lavender-top (EDTA) tube, green-top (sodium heparin) tube, tan-top (K2-EDTA) tube or pink-top (K2-EDTA) tube
Collection Instructions
Ship specimen at room temperature. Specimen should arrive in the laboratory within 48 hours of collection. Indicate date and time of collection on the request form.
Storage Instructions
Refrigerate. If specimen is to be stored prior to shipment, store at 2°C to 8°C.
Causes for Rejection
Specimen does not meet collection criteria; frozen whole blood, marrow, or cell pellet; leaking tube; clotted blood or marrow; grossly hemolyzed specimen or otherwise visibly degraded; contamination by another specimen; specimens containing suspicious foreign material