Galectin-3 With NT-proBNP

Casandra

Casandra Test Code LC86707Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 142005CPT Codes 82777, 83880

Galectin-3 With NT-proBNP

Also known as: NT-proBNP

Clinical Use

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Use

Galectin-3 is a biomarker of fibrosis and adverse remodeling, which is associated with a more progressive form of chronic heart failure. The BG Galectin-3 assay helps in assessing the prognosis of patients diagnosed with chronic heart failure. Elevated levels of galectin-3 have been observed in approximately 30% of NYHA class II/III outpatient populations, as well as in patients with both systolic dysfunction and preserved ejection fraction. Galectin-3 levels do not serve as a marker of cardiac distress or decompensation.

Special Instructions

This test may exhibit interference if the sample is collected from individuals consuming a supplement with high doses of biotin (vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask patients about biotin supplementation, and they should stop taking biotin at least 72 hours before sample collection. Galectin-3 levels are generally stable over time, and drugs for heart failure management often do not reduce galectin-3 levels.

Limitations

Galectin-3 levels lower than or equal to 17.8 ng/mL indicate a lower risk of adverse outcomes, while levels greater than 17.8 ng/mL indicate a higher risk. Levels between 17.8 ng/mL and 25.9 ng/mL should be interpreted with caution within the reference range. NT-proBNP cutpoints vary by age, helping diagnose or exclude heart failure in patients with acute dyspnea. Elevated galectin-3 may correlate with clinical variables such as age, gender, co-morbidities, and NYHA classification, but should not guide therapy changes.

Test Details

FDA Approved