Gastrin
Use
Diagnose Zollinger-Ellison (Z-E) syndrome; diagnose gastrinoma. Gastrin >1000 pg/mL with gastric acid hypersecretion (basal acid secretion >15 mmol/hour in a patient with peptic ulcer who has not had surgery) establishes unequivocally the diagnosis of the Zollinger-Ellison syndrome.4 Antral G-cell hyperplasia may relate to high gastrin levels and duodenal ulcer.
Special Instructions
Interference may occur if the sample is collected from individuals consuming high doses of biotin. It is advised to inquire about biotin supplementation and cease intake 72 hours before sample collection.
Limitations
Hyperacidity must be documented. Gastrin levels can be elevated due to various conditions such as gastric ulcer, chronic renal failure, and hyperparathyroidism. Medications like cimetidine may increase gastrin levels. Overlaps in gastrin values between gastrinoma and other conditions can occur, with up to 40% of Z-E patients having fasting gastrin levels between 100 and 500 pg/mL.
Methodology
Immunoassay (Immunochemiluminometric assay (ICMA))
Biomarkers
LOINC Codes
- 2333-3
- 2333-3
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells, transfer serum to a LabCorp PP transpak frozen purple tube with screw cap, and freeze immediately.
Patient Preparation
Patient must be fasting overnight, 12 to 14 hours.
Storage Instructions
Freeze immediately.
Causes for Rejection
Gross hemolysis, patient not fasting, specimen not received frozen, gross lipemia, plasma specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days |