Glucose 6-Phosphate Dehydrogenase (G6PD), Quantitative, Blood and Hemoglobin
Also known as: G6PD, Quantitative, Blood and Hgb, G6PDH
Use
Evaluate glucose 6-phosphate dehydrogenase (G6PD) deficiency. G6PD deficiency, an X-linked disorder, is the most common enzymatic disorder of red blood cells in humans, affecting more than 400 million people worldwide. The clinical expression of G6PD variants encompasses a spectrum of hemolytic syndromes. Affected patients are most often asymptomatic, but many patients have episodic anemia, while a few have chronic hemolysis.
Special Instructions
To prevent future hemolytic episodes, subjects with G6PD deficiency should avoid drugs and chemicals with oxidant potential. Hemolysis can be induced by drugs such as primaquine and certain sulfa drugs, as well as by fava beans and infections.
Limitations
False normal results after hemolysis may occur. Levels of G6PD are higher in the newborn than they are in the adult. When high levels are seen in older patients, it invariably reflects the presence of a young red blood cell population with reticulocytosis. G6PD values may be spuriously normal following a hemolytic crisis due to the presence of younger erythrocytes and reticulocytes.
Methodology
Automated Analyzer
Biomarkers
LOINC Codes
- 32546-4
- 718-7
- 32546-4
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
8 mL
Minimum Volume
Hemoglobin: two 500-μL lavender-top Microtainer™ tubes filled to at least 50% of tube capacity; G6PD: one lavender-top (EDTA) tube, green-top (heparin) tube or yellow-top (ACD) tube (0.1 mL) whole blood
Container
Two lavender-top (EDTA) tubes or one green-top (heparin) tube and one lavender-top (EDTA) tube or one yellow-top (ACD) tube and one lavender-top (EDTA) tube
Storage Instructions
Hemoglobin: Stable room temperature for 1 day or refrigerated for 72 hours. G6PD: Stable room temperature for 72 hours or refrigerated for seven days.
Causes for Rejection
Hemolysis; tube not filled with minimum fill volume; specimen drawn in any anticoagulant other than EDTA; specimens diluted or contaminated with IV fluid; clotted specimen; improper labeling; transfer tubes with whole blood; lavender-top (EDTA) tubes received with plasma removed; samples more than 72 hours old. G6PD: Frozen specimen.