Golimumab and Anti-Golimumab Antibody, DoseASSURE™ GOL
Also known as: DoseASSURE, Golimumab, Simponi
Use
The Golimumab and Anti-Golimumab Antibody, DoseASSURE™ GOL test is used for therapeutic drug monitoring of golimumab levels in serum. It assesses the presence and concentration of golimumab, a biologic used in the treatment of certain autoimmune conditions like rheumatoid arthritis and ulcerative colitis. The presence of anti-golimumab antibodies can suggest immunogenicity which may impact drug efficacy.
Special Instructions
Patients advised to stop biotin supplements 72 hours prior to sample collection to avoid interference with the assay. Serum/plasma must be separated from cells within 45 minutes of collection and sent in a plastic transport tube.
Limitations
Failure of golimumab therapy may not always be due to the presence of anti-golimumab antibodies, and the absence of these antibodies does not guarantee treatment effectiveness. High serum biotin concentrations can interfere with assay results.
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 87406-5
- 87406-5
- 87407-3
Result Turnaround Time
5-12 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3.0 mL
Minimum Volume
1.0 mL
Container
Serum-gel tube, red-top tube, or lavender-top (EDTA) tube
Collection Instructions
Serum/plasma must be separated from cells within 45 minutes of venipuncture. Send serum/plasma in a plastic transport tube.
Patient Preparation
Stop biotin 72 hours prior to sample collection.
Storage Instructions
Freeze.
Causes for Rejection
Gross hemolysis, gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | 7 days Stable x3 freeze/thaw cycles |