Gynecologic Pap Test (Image-guided), Liquid-based Preparation and Chlamydia/Gonococcus, NAA and Human Papillomavirus (HPV) (Aptima®)
Use
Diagnose primary or metastatic neoplasm; detect Chlamydia trachomatis and Neisseria gonorrhoeae. High-risk HPV test is used for types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68, without differentiation of the individual type.
Special Instructions
Include essential patient details such as date of birth, Social Security number, previous malignancies and treatments (chemotherapy, radiation), last menstrual period, postmenopausal status, recent surgeries, hormonal therapies, and history of abnormal Pap results on the cytology test request form. This ensures comprehensive assessment and accurate diagnostic interpretation. In case of reactive or reparative cellular changes, atypicity in squamous or glandular cells, or suspected pre-malignant or malignant findings, cases are referred for pathologist review with additional service charges.
Limitations
The Pap test may yield suboptimal results if adequate ectocervical, endocervical, or vaginal cell populations are not obtained. Overuse of lubricating jelly can interfere with cytologic examination, leading to unsatisfactory results. Multiplex use of cytology specimens may limit their availability for Pap reprocessing or HPV testing. Negative results cannot conclusively exclude HPV infection due to possible low-level infections or sampling errors causing false negatives. Only the 14 most common high-risk HPV types are detected. Special procedures are required for Chlamydia trachomatis and Neisseria gonorrhoeae testing which cannot be added post-specimen submission.
Methodology
Other
Biomarkers
LOINC Codes
- 47527-7
- 47528-5
- 19764-0
- 19773-1
- 19763-2
- 52797-8
- 22636-5
- 22638-1
- 22639-9
- 19767-3
- 19769-9
- 59420-0
- 50387-0
- 50388-8
- 8251-1
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Unknown)
Volume
ThinPrep® vial
Minimum Volume
Not provided
Container
ThinPrep® vial
Collection Instructions
Broom-like device: Insert brush into cervical os, rotate five times. Rinse in PreservCyt® solution by pushing and twirling brush. Discard. Brush/spatula: Insert brush into endocervical canal, rotate ¼-½ turn. Swirl in PreservCyt® solution. For Chlamydia/Gonococcus: Gen-Probe® Aptima® swab kit, follow kit instructions. Tighten vial cap securely.
Patient Preparation
Patient should avoid douches 48 to 72 hours prior to examination. Specimen should not be collected during or shortly after menstrual period.
Storage Instructions
Maintain at room temperature. Process Pap within 21 days, HPV within 21 days, Chlamydia/Gonococcus within 7 days.
Causes for Rejection
Improper collection, inadequate specimen, improper labeling, leaked specimen, inadequate quantity, name discrepancies, male patient submission, expired vial, frozen specimen, SurePath™ vial, specimen over 21 days for Pap/HPV, over 7 days for Chlamydia/Gonococcus, improper swab usage.