Gynecologic Pap Test (Image-guided), Liquid-based Preparation and Chlamydia/Gonococcus/Trichomonas, NAA With Reflex to Human Papillomavirus (HPV) (Aptima®) When ASC-U
Use
Diagnose primary or metastatic neoplasm; detect Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis. This test aids in the diagnosis of sexually transmitted HPV infection and in the triage of patients with an ASCUS Pap test result. High-risk HPV test is used for types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68, without differentiation of the individual type.
Special Instructions
Not provided.
Limitations
The test may yield suboptimal results if there is a failure to collect an adequate ectocervical, endocervical, or vaginal cell population. Excessive lubricant use can interfere with cytology results, and shared use of liquid-based cytology specimens might limit testing volume. A negative result does not guarantee the absence of HPV infection, as very low infection levels or errors in collection can result in false negatives. This test is limited to detecting only the 14 most common high-risk HPV types and does not provide individual type determination. Special procedures are necessary for processing the specimens for Chlamydia, Gonococcus, and Trichomonas, so testing cannot be added post-submission. Additionally, both Aptima® and ThinPrep® specimens are subject to strict stability and viability timelines.
Methodology
Other
Biomarkers
LOINC Codes
- 47527-7 - Cytology Cvx/Vag Doc Thin Prep
- 47528-5 - Cytology Cvx/Vag Doc Cyto
- 19764-0 - Stat of Adq Cvx/Vag Cyto-Imp
- 19763-2 - Specimen source Cvx/Vag Cyto
- 52797-8 - Dx ICD code
- 22636-5 - Path report.relevant Hx Spec
- 22638-1 - Path report.comments Imp Spec
- 22639-9 - Path report.supplemental reports Spec
- 19767-3 - Cytologist Cvx/Vag Cyto
- 19769-9 - Pathologist Cvx/Vag Cyto
- 50387-0 - C trach rRNA Cvx Ql NAA+probe
- 50388-8 - N gonorrhoea rRNA Cvx Ql NAA+probe
- 46154-1 - T vaginalis rRNA Spec Ql NAA+probe
Result Turnaround Time
2-6 days
Related Documents
For more information, please review the documents below
Specimen
Cervical Swab
Volume
ThinPrep® vial
Minimum Volume
Not provided
Container
ThinPrep® vial
Collection Instructions
ThinPrep® Vial − Broom or Brush/Spatula techniques involve specific procedures to ensure adequate collection and transfer to the vial.
Patient Preparation
Patient should avoid douches for 48 to 72 hours prior to examination. Specimen should not be collected during or shortly after menstrual period.
Storage Instructions
Maintain specimen at room temperature. Specimens must be processed within 21 days of collection for Pap.
Causes for Rejection
Improper collection; inadequate specimen; improper labeling; specimen leaked in transit; quantity not sufficient for analysis; name discrepancies; submission on male patient; expired vial; frozen specimen; SurePath™ vial.