Gynecologic Pap Test (Image-guided), Liquid-based Preparation and Chlamydia/Gonococcus/Trichomonas, NAA With Reflex to Human Papillomavirus (HPV) (Aptima®) When ASC-U
Use
Diagnose primary or metastatic neoplasm; detect Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis. This test aids in the diagnosis of sexually transmitted HPV infection and in the triage of patients with an ASCUS Pap test result. High-risk HPV test is used for types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68, without differentiation of the individual type.
Special Instructions
The test requires detailed clinical information for proper processing, including patient identifiers and relevant medical history such as previous malignancy and recent treatments. It must also detail any relevant gynecological history like last menstrual period and any use of exogenous hormones. In certain cases, LabCorp will review slides under pathologist guidance, incurring additional charges. Specimens must be appropriately labeled and collected as per specified techniques to avoid errors in analysis.
Limitations
The test may yield suboptimal results if there is a failure to collect an adequate ectocervical, endocervical, or vaginal cell population. Excessive lubricant use can interfere with cytology results, and shared use of liquid-based cytology specimens might limit testing volume. A negative result does not guarantee the absence of HPV infection, as very low infection levels or errors in collection can result in false negatives. This test is limited to detecting only the 14 most common high-risk HPV types and does not provide individual type determination. Special procedures are necessary for processing the specimens for Chlamydia, Gonococcus, and Trichomonas, so testing cannot be added post-submission. Additionally, both Aptima® and ThinPrep® specimens are subject to strict stability and viability timelines.
Methodology
Other
Biomarkers
LOINC Codes
- 47527-7
- 47528-5
- 19764-0
- 19763-2
- 52797-8
- 22636-5
- 22638-1
- 22639-9
- 19767-3
- 19769-9
- 50387-0
- 50388-8
- 46154-1
Result Turnaround Time
2-6 days
Related Documents
For more information, please review the documents below
Specimen
Cervical Swab
Volume
ThinPrep® vial
Minimum Volume
Not provided
Container
ThinPrep® vial
Collection Instructions
ThinPrep® Vial − Broom or Brush/Spatula techniques involve specific procedures to ensure adequate collection and transfer to the vial.
Patient Preparation
Patient should avoid douches for 48 to 72 hours prior to examination. Specimen should not be collected during or shortly after menstrual period.
Storage Instructions
Maintain specimen at room temperature. Specimens must be processed within 21 days of collection for Pap.
Causes for Rejection
Improper collection; inadequate specimen; improper labeling; specimen leaked in transit; quantity not sufficient for analysis; name discrepancies; submission on male patient; expired vial; frozen specimen; SurePath™ vial.