Gynecologic Pap Test (Image-guided), Liquid-based Preparation With Reflex to High-risk HPV (Cobas®) When ASC-U
Use
Diagnose primary or metastatic neoplasm. The high-risk HPV test is used for types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68, without differentiation of the individual type. This assay aids in the diagnosis of sexually-transmitted HPV infection and in the triage of patients with an ASCUS Pap smear result.
Special Instructions
Ensure to include date of birth, Social Security number, previous malignancy, drug therapy, radiation therapy, last menstrual period, postmenopausal status, surgeries, exogenous hormones, abnormal vaginal bleeding, abnormal Pap results, IUD use, and other pertinent clinical information on the cytology test request form.
Limitations
The test may not provide adequate evaluation if there is failure to obtain adequate ectocervical, endocervical, or vaginal cell population. Excessive use of lubricating jelly can interfere with examination, leading to unsatisfactory results. Limited specimen volume may affect Pap or HPV testing. HPV detection is dependent on the number of copies present and may be influenced by collection methods, patient factors, and interfering substances.
Methodology
Other
Biomarkers
LOINC Codes
- 47527-7
- 47528-5
- 19764-0
- 19773-1
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Other
Volume
ThinPrep® vial
Minimum Volume
Not provided
Container
ThinPrep® vial
Collection Instructions
Use brush/spatula technique: Insert brush into endocervical canal, rotate 1/4 to 1/2 turn, rotate in PreservCyt® solution 10 times. Obtain ectocervix sample with spatula, swirl in vial, tighten cap properly.
Patient Preparation
Avoid douches 48-72 hours prior. Do not collect during or shortly after menstrual period.
Storage Instructions
Store at room temperature. Pap processing within 21 days. Store up to six months for Cobas® HPV test.
Causes for Rejection
Improper collection, inadequate specimen, improper labeling, frozen specimen, leakage, insufficient quantity, discrepancies, overaged specimens.