Gynecologic Pap Test, Liquid-based Preparation With Maturation Index
Also known as: Maturation Index With Pap Test
Use
The Gynecologic Pap Test, utilizing liquid-based preparation, is a screening test designed to aid in the detection of premalignant and malignant conditions of the uterine cervix. The inclusion of the maturation index allows for additional assessment of hormonal status and cellular changes, aiding in the determination of potential disorders. Although primarily a screening tool, this test is crucial in the early detection of cervical cancer and other significant genital health issues.
Special Instructions
Include the patient's date of birth, Social Security number (or other identification number), previous malignancy, drug therapy, radiation therapy, last menstrual period (LMP), postmenopausal status (PMP), any surgical history (including biopsies), use of exogenous hormones, incidences of abnormal vaginal bleeding, previous abnormal Pap results, presence of an IUD, and any other pertinent clinical information on the cytology test request form. In accordance with CLIA criteria, samples will be referred for pathologist review in cases of reactive cellular changes, atypical squamous or glandular cells of undetermined significance, or cells in premalignant or malignant categories. Additional service charges apply for pathologist reviews.
Limitations
The test has limitations in that a failure to obtain a satisfactory vaginal cell population renders the specimen unsatisfactory for evaluation. The use of excessive lubricating jelly on the vaginal speculum compromises the cytologic examination. Both false-positive and false-negative reports can occur, emphasising its role as a screening rather than diagnostic tool.
Methodology
Other
Biomarkers
LOINC Codes
- 47528-5
- 19764-0
- 19773-1
- 19763-2
- 52797-8
- 22636-5
- 22639-9
- 22638-1
- 8251-1
- 19769-9
- 19767-3
- 19765-7
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Vaginal Swab
Volume
Entire vial
Minimum Volume
Not provided
Container
ThinPrep® vial or SurePath™ vial
Collection Instructions
Use cervix brush to obtain cells from the upper third of the lateral vaginal wall. Rotate the brush in PreservCyt® solution 10 times while pushing against the wall of the vial, then swirl vigorously to release additional material. Discard the brush, securing the cap tightly. Record patient's details on the vial and place it with the test request form in a specimen bag for transport.
Patient Preparation
Avoid douches 48-72 hours before examination. Do not collect specimen during or immediately after menstrual period. Avoid excessive lubricating jelly use.
Storage Instructions
Maintain specimen at room temperature. Must process specimen within 21 days of collection.
Causes for Rejection
Improper labeling, specimen over 21 days old in preservative, expired vial, frozen specimen