Histamine Determination, Plasma
Also known as: Plasma Histamine
Use
This test is used for the measurement of histamine in plasma.
Special Instructions
This test is not the Leukocyte Histamine Release Test (LHRT). It requires specific specimen handling, including plasma separation and immediate freezing, to prevent delays in turnaround time. Separate frozen specimens are recommended for multiple test requests to ensure optimal conditions during analysis.
Limitations
The test was developed and its performance characteristics were determined by Labcorp and have not been cleared or approved by the FDA. Plasma histamine levels may indicate exposure to histamine or other stimuli, but they are less specific for mast cell activation compared to serum tryptase levels. Elevated histamine may occur due to dietary intake, food processing issues, or substance interactions affecting amine oxidase activity.
Methodology
Immunoassay (EIA)
Biomarkers
LOINC Codes
- 2416-6
- 2416-6
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
1 mL
Container
Lavender-top (EDTA) tube
Collection Instructions
Separate plasma and transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze
Causes for Rejection
Gross lipemia; gross hemolysis; gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unstable |
| Frozen | 14 days |