HLA A,B,C,DRB1 CWD Resolution
Use
HLA antigens may be correlated with certain disease states or other clinical conditions. Indicate in clinical information which antigen(s) is of interest. Also used for screening of transplant candidates and potential donors, transfusion of specifically compatible blood products, among others.
Special Instructions
Not provided.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. CWD resolution typing for HLA will meet the following criteria: The typing must contain only one unambiguously assigned genotype, or the typing may contain multiple alternative genotypes if one includes two Common and Well Documented (CWD) alleles and the others do not include any CWD allele. Alleles that encode identical protein sequences in the antigen recognition site (ARS) will not be resolved even if they are CWD. Rare or unusual allele combinations may not be ruled out. Allele codes will be reported to include those alleles that are not ruled out.
Methodology
NGS (Sanger)
Biomarkers
No genes
Gene
LOINC Codes
- 57298-2 - HLA-DRB1
- 49549-9 - Ref lab test method
- 13298-5 - HLA-A
- 57291-7 - HLA-B High Res
- 42664-3 - HLA-Cw
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
7 mL
Minimum Volume
3 mL
Container
Lavender-top (EDTA) tube
Storage Instructions
Maintain specimen at room temperature; protect from extreme heat or cold. Do not freeze.
Causes for Rejection
Hemolyzed specimen; clotted specimen; wrong specimen container
Other tests from different labs that may be relevant