HLA B*58:01, Allopurinol Hypersensitivity

Casandra

Casandra Test Code LC22790Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 167351CPT Code 81381

HLA B*58:01, Allopurinol Hypersensitivity

Also known as: Allopurinol Hypersensitivity, B58, B5801, HLA B*58:01, HLA B58

Clinical Use

Order Test

Use

Allopurinol associated SCAR (severe cutaneous adverse drug reaction) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been shown to be associated with the human leukocyte antigen (HLA) B*58:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T-cell receptors to elicit an immune response. The presence of the HLA B*58:01 allele increases the susceptibility to allopurinol SCAR in several populations studied.

Special Instructions

Not provided.

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, an additional specimen should be collected for retesting.

Test Details