HLA B*58:01, Allopurinol Hypersensitivity
Also known as: Allopurinol Hypersensitivity, B58, B5801, HLA B*58:01, HLA B58
Use
Allopurinol associated SCAR (severe cutaneous adverse drug reaction) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been shown to be associated with the human leukocyte antigen (HLA) B*58:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T-cell receptors to elicit an immune response. The presence of the HLA B*58:01 allele increases the susceptibility to allopurinol SCAR in several populations studied.
Special Instructions
Not provided.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. Even with appropriate precautions, an occasional specimen may not be satisfactory for testing. In such cases, an additional specimen should be collected for retesting.
Methodology
NGS
Biomarkers
No genes
Gene
LOINC Codes
- 13299-3 - HLA-B
- 13299-3 - HLA-B
- 49549-9 - Ref lab test method
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
7 mL
Minimum Volume
7 mL
Container
Lavender-top (EDTA) tube
Storage Instructions
Maintain whole blood at room temperature or refrigerate.
Causes for Rejection
Hemolysis; clotted specimen; insufficient volume of DNA
Other tests from different labs that may be relevant