Human Immunodeficiency Virus 1 (HIV-1) Trofile® DNA (Monogram® Coreceptor Tropism), Whole Blood
Use
Detect HIV-1 coreceptor tropism; determine eligibility for CCR5 antagonist therapy such as Selzentry™ (maraviroc).
Special Instructions
The test employs polymerase chain reaction (PCR) amplification and viral culture methodologies. Trofile™ is a registered trademark of Monogram Biosciences. Be aware that additional time may be required for further confirmatory or reflex testing. For optimal turnaround times, ensure separate frozen specimens are submitted if multiple tests are requested.
Limitations
This test should be used only for patients with documented HIV-1 infection and undetectable viral loads. It has been developed and its performance characteristics determined by Labcorp. However, it has not been cleared or approved by the Food and Drug Administration, which may limit its use in certain clinical settings.
Methodology
PCR-based
Biomarkers
LOINC Codes
- 51969-4
- 80690-1
- 50790-5
- 62364-5
Result Turnaround Time
29-33 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
4 mL
Minimum Volume
Not provided
Container
Lavender-top (EDTA) tube
Collection Instructions
Collect specimen in lavender-top (EDTA) tube. Do not centrifuge. Ship frozen. To avoid delays in turnaround time, when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze.
Causes for Rejection
Insufficient volume; heparinized plasma; nonfrozen specimen