Human Papillomavirus (HPV) High-risk (Cobas®) With HPV 16 and 18, Rectal Source
Use
Specifically identifies types HPV 16 and HPV 18 while concurrently detecting the rest of the high-risk types: 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68, without further specific differentiation.
Special Instructions
The test uses a nucleic acid amplification methodology, offering a sensitive detection process. Results are given based on the presence of specific HPV types within samples collected from the rectal region using a specific collection and processing protocol.
Limitations
The detection of HPV is highly dependent on the number of copies present in the specimen, which can be influenced by the method of specimens collection, the patient's individual factors, the stage of infection, and possible presence of substances that could interfere with the detection process. Proper collection technique is critical for accurate results.
Methodology
PCR-based (Nucleic acid amplification (NAA))
Biomarkers
LOINC Codes
- 77376-2
- 77394-5
- 77396-0
- 77395-2
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Other
Volume
2 mL
Minimum Volume
1 mL
Container
ThinPrep® vial only
Collection Instructions
An anal-rectal cytology specimen is collected using a Dacron swab. Moisten the swab in tap water and insert as far as possible into the anal canal. Rotate the swab in one direction with gentle pressure on the walls as it is slowly being withdrawn, ensuring the transition zone is sampled. Vigorously rotate the swab in the PreservCyt® solution 10 times while pushing against the wall of the ThinPrep® vial. Swirl the swab vigorously and discard the swab. Tighten the cap on the ThinPrep® container so that the torque line on the cap passes the torque line on the vial.
Storage Instructions
Room temperature
Causes for Rejection
Improper collection or inadequate specimen; improperly labeled; specimen more than six months old in ThinPrep® vial; frozen specimens; specimen leaked in transit; quantity not sufficient for analysis; name discrepancies; excessively bloody specimens.