Immune Complexes, C1q Binding
Also known as: C1q Binding, C1q Binding Test, C1q Immune Complexes, Circulating Immune Complexes, Complement C1q Immune Complexes
Use
Monitor immune complex disease (ie, lupus, glomerulonephritis, serum hepatitis, arthritis, vasculitis); monitor progress of some malignancies
Special Instructions
Samples must be stored frozen prior to transport to ensure integrity. It is crucial to separate serum from cells and transfer the specimen to a plastic transport tube before freezing to prevent delays in test processing. When ordering multiple frozen tests, individual samples should be submitted for each test to avoid testing delays.
Limitations
The World Health Organization/International Union of Immunological Societies (WHO/IUIS) survey of laboratory tests in clinical immunology determined that detecting circulating immune complexes is not necessary for any specific diagnosis. Hemolysis and improper thawing of specimens can lead to rejected samples or false-positive results. The test is limited by the need to avoid repeated thawing and freezing to maintain sample integrity.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 27831-7
- 27831-7
Result Turnaround Time
4-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.1 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells. Transfer specimen to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze prior to transport. Samples may be stored at 2°C to 8°C for seven days prior to testing.
Causes for Rejection
Hemolysis; heating specimen for thawing may give false-positive results, avoid repeated thawing and freezing.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |