Integrated 1
Also known as: Down Syndrome, Nuchal Translucency (NT), PAPP-A
Use
Screening test for open neural tube defects, Down syndrome, and trisomy 18
Special Instructions
For test inquiries, call CMBP genetic services at 800-345-4363. Client must provide fetal nuchal translucency (NT) measurement and crown rump length measurement. The NT measurement must be performed by a sonographer credentialed by the Fetal Medicine Foundation or an equivalent entity. Complete information is necessary to interpret the test. Patient information may be provided using the Maternal Prenatal Screening requisition 0900.
Limitations
This screening test requires two specimens: one collected in the first trimester and one in the second trimester. The result interpretation will only be provided when the second trimester specimen is received and tested. A positive result indicates that additional diagnostic testing may be needed to confirm the presence of a neural tube defect or chromosome abnormality. The test does not screen for open spina bifida (OSB) in the first trimester.
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 49586-1
- 12146-7
- 48407-1
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Gel-barrier tube
Collection Instructions
Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory. Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |