MaterniT21 Genome Add On
Use
The MaterniT Genome test provides comprehensive chromosome copy number analysis including unbalanced derivatives, and information about deletions or duplications of chromosome material 7 Mb or larger, as well as analysis of seven clinically relevant microdeletions less than 7 Mb in size.
Special Instructions
This test can only be ordered if the MaterniT21 PLUS test has been previously performed. Required information with the test request form includes patient's date of birth, gestational age, pregnancy type (singleton), donor egg status, and clinical indications such as advanced maternal age, abnormal ultrasound, or a history suggestive of increased aneuploidy risk.
Limitations
These tests are highly accurate but may yield discordant or inaccurate results due to factors such as placental, maternal, or fetal mosaicism, vanishing twin, prior maternal organ transplant, or more. The test is not validated for multifetal gestations and cannot replace CVS or amniocentesis. It does not assure against other chromosomal abnormalities or birth defects, and maternal conditions or medications may impact results. Pregnancy decisions should not rely solely on this test; genetic counseling is recommended for positive results.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 53693-8
- 75605-6
- 75980-3
- 72486-4
- 75558-7
- 73824-5
- 75693-2
- 75570-2
- 79211-9
- 92903-4
- 92899-4
- 92902-6
- 92900-0
- 75602-3
- 77202-0
- 49549-9
- 62364-5
- 8251-1
- 75608-0
- 51969-4
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
Not provided
Container
Black-and-tan-top (Streck) tube
Collection Instructions
Only the Sequenom collection kit (PeopleSoft No. 116373) can be used for collection.
Storage Instructions
Room temperature. Do not refrigerate or freeze. Keep out of direct sunlight. Samples must be shipped to LabCorp in a Sequenom collection kit.
Causes for Rejection
Gestational age less than nine weeks; expired or incorrect blood tubes; quantity not sufficient; received more than seven days from collections; excessive hemolysis; frozen specimens