MaterniT21 Genome Add On Redraw
Use
The MaterniT Genome test provides comprehensive chromosome copy number analysis including unbalanced derivatives, and information about deletions or duplications of chromosome material 7 Mb or larger, as well as analysis of seven clinically relevant microdeletions less than 7 Mb in size.
Special Instructions
Not provided.
Limitations
Although highly accurate, the MaterniT Genome test results might be discordant due to factors like placental, maternal, or fetal mosaicism, vanishing twin, or previous maternal organ transplant. Sex chromosomal aneuploidies are not reportable for multiple gestations as the assay is not validated for multifetal gestations. This is a screening test only and not a diagnostic tool, thus cannot replace prenatal diagnosis methods like CVS or amniocentesis. A positive result should prompt genetic counseling and possibly an invasive prenatal diagnostic procedure for confirmation. The test does not detect neural tube or ventral wall defects, triploidy, or balanced rearrangements. Factors such as maternal BMI, systemic lupus erythematosus, and certain medications might impact result accuracy.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 92900-0 - Fet Chr 4p16 Del Plas.cfDNA Ql
- 75602-3 - Fet 1p36 del risk WBC.DNA+cfDNA Ql
- 75983-7 - Fet Chr 21 Ts Plas.cfDNA Ql
- 75558-7 - Fet Ts 18 risk WBC.DNA+cfDNA Ql
- 73824-5 - Fet Ts 13 risk Plas.cfDNA Ql
- 75693-2 - Fet sex Plas.cfDNA Dosage cfDNA
- 75570-2 - Fet Ms X risk WBC.DNA+cfDNA Ql
- 79211-9 - Fet X + Y aneup risk Plas.cfDNA Seq-Imp
- 75578-5 - Fet 22q11.2 del risk WBC.DNA+cfDNA Ql
- 92903-4 - Fet Chr 15q11 Del Plas.cfDNA Ql
- 92899-4 - Fet Chr 11q23 Del Plas.cfDNA Ql
- 92902-6 - Fet Chr 8q24 Del Plas.cfDNA Ql
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
8 mL
Container
Black-and-tan-top (Streck) tube
Collection Instructions
Only the Sequenom collection kit (PeopleSoft No. 116373) can be used for collection.
Storage Instructions
Room temperature. Do not refrigerate or freeze. Keep out of direct sunlight. Samples must be shipped to LabCorp in a Sequenom collection kit.
Causes for Rejection
Gestational age less than nine weeks; expired or incorrect blood tubes (including nonglass tubes); quantity not sufficient for analysis; received more than seven days from collections; excessive hemolysis; frozen specimens
Other tests from different labs that may be relevant