MaterniT21 PLUS Core + ESS
Use
For pregnancies at increased risk of fetal abnormalities, the MaterniT21 PLUS test delivers a comprehensive NIPT for the analysis of chromosomal regions including trisomies 21, 18, and 13, fetal sex, and an enhanced sequencing series that examines seven clinically relevant microdeletions and two additional chromosomal regions, trisomies 22 and 16.
Special Instructions
The test request form must include the patient's date of birth, gestational age, pregnancy type (singleton or multiple), donor egg status, and clinical indications. It is crucial to provide all necessary demographic information for accurate processing.
Limitations
Results may not be entirely accurate due to factors such as placental, maternal, or fetal mosaicism, maternal organ transplantation history, or vanishing twin. This test does not replace more definitive methods like CVS or amniocentesis, and is not a substitute for detecting pregnancies at risk for neural tube or ventral wall defects. Factors such as maternal BMI, weight, and SLE may affect results. Further genetic counseling and testing are advised for positive or high risk scores. cfDNA testing may not detect fetal triploidy, balanced chromosomal rearrangements, or precise locations of subchromosomal changes.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 92899-4
- 92902-6
- N/A
- 92900-0
- 75602-3
- 77202-0
- 49549-9
- 62364-5
- 8251-1
- 75608-0
- 51969-4
- 53693-8
- 75605-6
- 75980-3
- 72486-4
- 75983-7
- 75558-7
- 73824-5
- 75693-2
- 75578-5
- 92903-4
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
(1) 10 mL
Minimum Volume
8 mL
Container
Black-and-tan-top (Streck) tube (whole blood).
Collection Instructions
Only the Sequenom collection kit PS#116373 can be used for collection.
Storage Instructions
Room temperature. Do not refrigerate or freeze. Keep out of direct sunlight. Samples must be shipped to LabCorp in a Sequenom collection kit.
Causes for Rejection
Gestational age less than nine weeks; expired or incorrect blood tubes; quantity not sufficient for analysis; more than seven days from collection; excessive hemolysis; frozen specimens