MaterniT21 PLUS Core + ESS
Use
For pregnancies at increased risk of fetal abnormalities, the MaterniT21 PLUS test delivers a comprehensive NIPT for the analysis of chromosomal regions including trisomies 21, 18, and 13, fetal sex, and an enhanced sequencing series that examines seven clinically relevant microdeletions and two additional chromosomal regions, trisomies 22 and 16.
Special Instructions
Not provided.
Limitations
Results may not be entirely accurate due to factors such as placental, maternal, or fetal mosaicism, maternal organ transplantation history, or vanishing twin. This test does not replace more definitive methods like CVS or amniocentesis, and is not a substitute for detecting pregnancies at risk for neural tube or ventral wall defects. Factors such as maternal BMI, weight, and SLE may affect results. Further genetic counseling and testing are advised for positive or high risk scores. cfDNA testing may not detect fetal triploidy, balanced chromosomal rearrangements, or precise locations of subchromosomal changes.
Methodology
NGS (Targeted)
Biomarkers
No genes
GeneUnknown CNV
Copy Number Region
LOINC Codes
- 92899-4 - Fet Chr 11q23 Del Plas.cfDNA Ql
- 92902-6 - Fet Chr 8q24 Del Plas.cfDNA Ql
- N/A
- 92900-0 - Fet Chr 4p16 Del Plas.cfDNA Ql
- 75602-3 - Fet 1p36 del risk WBC.DNA+cfDNA Ql
- 77202-0 - Laboratory comment Report
- 49549-9 - Ref lab test method
- 62364-5 - Test performance info Spec
- 8251-1 - Service Cmnt-Imp
- 75608-0 - Citation Ref Lab Test
- 51969-4 - Gene analysis narr rpt Doc
- 53693-8 - GA Est from conception date
- 75605-6 - cfDNA.fet/cfDNA.total SFr Fetus
- 75980-3 - Fet 13+18+21+X+Y aneup Plas.cfDNA
- 72486-4 - Lab director name Provider
- 75983-7 - Fet Chr 21 Ts Plas.cfDNA Ql
- 75558-7 - Fet Ts 18 risk WBC.DNA+cfDNA Ql
- 73824-5 - Fet Ts 13 risk Plas.cfDNA Ql
- 75693-2 - Fet sex Plas.cfDNA Dosage cfDNA
- 75578-5 - Fet 22q11.2 del risk WBC.DNA+cfDNA Ql
- 92903-4 - Fet Chr 15q11 Del Plas.cfDNA Ql
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
(1) 10 mL
Minimum Volume
8 mL
Container
Black-and-tan-top (Streck) tube (whole blood).
Collection Instructions
Only the Sequenom collection kit PS#116373 can be used for collection.
Storage Instructions
Room temperature. Do not refrigerate or freeze. Keep out of direct sunlight. Samples must be shipped to LabCorp in a Sequenom collection kit.
Causes for Rejection
Gestational age less than nine weeks; expired or incorrect blood tubes; quantity not sufficient for analysis; more than seven days from collection; excessive hemolysis; frozen specimens
Other tests from different labs that may be relevant