MaterniT21 PLUS Core + ESS + SCA
Use
For pregnancies at increased risk of fetal abnormalities, the MaterniT21 PLUS test delivers a comprehensive NIPT for the analysis of chromosomal regions including trisomies 21, 18, and 13, fetal sex, sex chromosome aneuploidies, and an enhanced sequencing series that examines seven clinically relevant microdeletions and two additional chromosomal regions, trisomies 22 and 16.
Special Instructions
Not provided.
Limitations
Although the results are highly accurate, discordant outcomes can occur due to biological factors like placental, maternal, or fetal mosaicism, maternal organ transplants, or vanishing twins. The test does not replace the precision of prenatal diagnosis with CVS or amniocentesis. It may not accurately detect fetal triploidy, balanced rearrangements, or the precise locations of duplications or deletions, and the results could be impacted by maternal BMI, weight, or systemic lupus erythematosus. Further genetic counseling and invasive prenatal testing might be necessary for evaluating positive or nonreportable results.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 53693-8 - GA Est from conception date
- 75605-6 - cfDNA.fet/cfDNA.total SFr Fetus
- 75980-3 - Fet 13+18+21+X+Y aneup Plas.cfDNA
- 75983-7 - Fet Chr 21 Ts Plas.cfDNA Ql
- 75558-7 - Fet Ts 18 risk WBC.DNA+cfDNA Ql
- 73824-5 - Fet Ts 13 risk Plas.cfDNA Ql
- 75693-2 - Fet sex Plas.cfDNA Dosage cfDNA
- 75570-2 - Fet Ms X risk WBC.DNA+cfDNA Ql
- 79211-9 - Fet X + Y aneup risk Plas.cfDNA Seq-Imp
- 75578-5 - Fet 22q11.2 del risk WBC.DNA+cfDNA Ql
- 92903-4 - Fet Chr 15q11 Del Plas.cfDNA Ql
- 92899-4 - Fet Chr 11q23 Del Plas.cfDNA Ql
- 92902-6 - Fet Chr 8q24 Del Plas.cfDNA Ql
- 92900-0 - Fet Chr 4p16 Del Plas.cfDNA Ql
- 75602-3 - Fet 1p36 del risk WBC.DNA+cfDNA Ql
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
8 mL
Container
Black-and-tan-top (Streck) tube
Collection Instructions
Only the Sequenom collection kit PS#116373 can be used for collection.
Storage Instructions
Room temperature. Do not refrigerate or freeze. Keep out of direct sunlight. Samples must be shipped to LabCorp in a Sequenom collection kit.
Causes for Rejection
Gestational age less than nine weeks; expired or incorrect blood tubes; quantity not sufficient; received more than seven days from collection; excessive hemolysis; frozen specimens
Other tests from different labs that may be relevant