MaterniT21 PLUS Core + SCA, NO Gender
Use
For pregnancies at increased risk of fetal abnormalities, the MaterniT21 PLUS test delivers a comprehensive NIPT for the analysis of chromosomal regions including trisomies 21, 18, and 13, and sex chromosome aneuploidies.
Special Instructions
The test requires information such as the patient's date of birth, gestational age, pregnancy type (singleton or multiple), donor egg status, and clinical indications like advanced maternal age or abnormal ultrasound findings. The test must be ordered using the Sequenom collection kit (PS#116373).
Limitations
The results, while highly accurate, can be affected by conditions such as placental, maternal, or fetal mosaicism or neoplasm, vanishing twin syndrome, prior maternal organ transplant, and maternal weight. cfDNA testing is limited in its ability to detect neural tube defects, ventral wall defects, fetal triploidy, or precise subchromosomal duplications or deletions. A positive result should prompt genetic counseling and possibly additional invasive testing like CVS or amniocentesis.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 53693-8
- 75605-6
- 75980-3
- 72486-4
- 75983-7
- 75558-7
- 73824-5
- 75693-2
- 75570-2
- 79211-9
- 75608-0
- 8251-1
- 51969-4
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
5 mL
Container
Black-and-tan-top (Streck) tube
Collection Instructions
Only the Sequenom collection kit PS#116373 can be used for collection.
Storage Instructions
Room temperature. Do not refrigerate or freeze. Keep out of direct sunlight. Samples must be shipped to LabCorp in a Sequenom collection kit.
Causes for Rejection
Gestational age less than nine weeks; expired or incorrect blood tubes (including nonglass tubes); quantity not sufficient for analysis; received more than seven days from collections; excessive hemolysis; frozen specimens