Metanephrines, Pheochromocytoma Evaluation
Also known as: Metanephrines, Random Urine, Pheochromocytoma Evaluation
Use
Diagnose the presence of a pheochromocytoma, neuroblastoma, and ganglioneuroblastoma
Special Instructions
Simultaneous measurement of urine creatinine allows for the expression of the metanephrine:creatinine ratio. Clinicians often use a threshold of >2.2 μg metanephrines/mg creatinine to differentiate pheochromocytoma from normal conditions, although individual clinical judgment is required to interpret test results in the context of patient-specific factors such as medications and dietary influences.
Limitations
The test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration. Results may be influenced by medication and dietary factors; specific dietary items such as bananas, pineapple, and plums should be avoided before and during specimen collection. The test may not detect all cases of pheochromocytoma due to variable tumor catecholamine secretion or low-volume tumor mass.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 68317-7
- 2161-8
- 21422-1
- 21019-5
- 13771-1
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
10 mL
Minimum Volume
2.5 mL
Container
Random urine transport tube with no preservative or 6N HCl
Collection Instructions
Collect urine and transfer to a random urine transport tube.
Patient Preparation
Medication and dietary monitoring. A number of drugs act through catecholamine mechanisms and must be discontinued 72 hours before and during collection. Bananas, pineapple, and plums are contraindicated.
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |