MLH1/MSH2/MSH6/PMS2/EPCAM Somatic Tumor Mismatch Repair Sequencing and Deletion/Duplication Test
Also known as: EPCAM, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, IMCAN Tumor, Mismatch Repair Somatic
Use
Tumors with mismatch repair deficiency as determined by MSI or IHC are suspected for HNPCC, Lynch or Lynch-like syndrome. This test will assess the tumor for a pathogenic genetic variant which, if found, may be evaluated in blood to determine germline/hereditary status.
Special Instructions
Testing is referred to Impact Genetics, located in Ontario, Canada. A pathology report including MSI or IHC is required for this test. For any inquiries regarding this test, please contact 877-624-9769.
Limitations
The test was developed and performance characteristics were determined by Impact Genetics. It has not been cleared or approved by the US Food and Drug Administration (FDA).
Methodology
NGS
Biomarkers
LOINC Codes
- 41103-3
Result Turnaround Time
21-28 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
FFPE block or 19 serial unstained unbaked slides
Minimum Volume
Not provided
Container
blocks or slides
Storage Instructions
Fixed tissue is stable indefinitely. Room temperature storage.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 5 days |