Nonsevere Hemophilia A Profile
Use
This profile is appropriate for the evaluation of individuals suspected of or previously identified as having nonsevere (mild or moderate) hemophilia A, in order to determine if there is a twofold discrepancy in the one stage and chromogenic factor VIII activities as has been described in discrepant hemophilia A. Evaluation for nonsevere hemophilia A using a one stage (clot-based) activity assay only may lead to missed diagnosis or misclassification of disease severity.
Special Instructions
Plasma must be separated from cells within three hours of venipuncture and plasma centrifuged a second time before being placed in plastic transport tubes. Freeze within four hours and keep frozen until testing is performed.
Limitations
Testing using only a one-stage (clot-based) activity assay may miss the diagnosis or misclassify the severity of nonsevere hemophilia A. The test has not been validated for the monitoring of unfractionated heparin therapy, and aPTT-based ranges for this therapy have not been established.
Methodology
See individual tests
Biomarkers
LOINC Codes
- 14979-9
- 3209-4
- 49865-9
- 21026-0
Result Turnaround Time
4-7 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
4 mL
Minimum Volume
2 mL
Container
Blue-top (sodium citrate) tube
Collection Instructions
Plasma must be separated from cells within three hours of venipuncture and plasma centrifuged a second time before being placed in plastic transport tubes. Freeze within four hours and keep frozen until testing is performed.
Storage Instructions
Freeze
Causes for Rejection
Noncitrated plasma; gross hemolysis; fibrin clot in plasma; sample received thawed