Nonsevere Hemophilia A Profile

Clinical Use

Use

This profile is appropriate for the evaluation of individuals suspected of or previously identified as having nonsevere (mild or moderate) hemophilia A, in order to determine if there is a twofold discrepancy in the one stage and chromogenic factor VIII activities as has been described in discrepant hemophilia A. Evaluation for nonsevere hemophilia A using a one stage (clot-based) activity assay only may lead to missed diagnosis or misclassification of disease severity.

Special Instructions

Not provided.

Limitations

Testing using only a one-stage (clot-based) activity assay may miss the diagnosis or misclassify the severity of nonsevere hemophilia A. The test has not been validated for the monitoring of unfractionated heparin therapy, and aPTT-based ranges for this therapy have not been established.

Test Details

Methodology

See individual tests

Biomarkers

4 components

aPTT • CoagulationFactor VIII Activity • CoagulationFactor VIII Chromogenic • CoagulationPathologist Interpretation

LOINC Codes

Result Codes

14979-9 - aPTT PPP
3209-4 - Fact VIII Act/Nor PPP
49865-9 - Fact VIII Act/Nor PPP Chro
21026-0 - Path Interp Bld-Imp

Result Turnaround Time

4-7 days

Specimen

Plasma

Volume

4 mL

Minimum Volume

2 mL

Container

Blue-top (sodium citrate) tube

Collection Instructions

Plasma must be separated from cells within three hours of venipuncture and plasma centrifuged a second time before being placed in plastic transport tubes. Freeze within four hours and keep frozen until testing is performed.