NT-proBNP

Casandra

Casandra Test Code LC66276Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 143000CPT Code 83880

Also known as: proBNP, Propeptide of Brain Natriuretic Peptide

Clinical Use

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Use

This assay is used as an aid in the diagnosis of individuals suspected of having congestive heart failure. The test is further indicated for the risk stratification of patients with acute coronary syndrome and congestive heart failure. The test may also serve as an aid in the assessment of increased risk of cardiovascular events and mortality in patients at risk for heart failure who have stable coronary artery disease.

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Limitations

NT-proBNP values should be assessed in conjunction with other cardiovascular risk factors and clinical findings. Interpreting results in the setting of comorbidities such as cardiac, pulmonary, and renal disease, which are likely to increase natriuretic peptides above current thresholds for HF, should be done with caution. The accuracy of natriuretic peptides for the detection of HF is reduced in the setting of atrial fibrillation and sepsis, and careful interpretation is warranted.

Test Details