PD-L1 IHC (Nivolumab) Squamous Cell Carcinoma of the Head and Neck
Also known as: OPDIVO®, Programmed Death Ligand 1
Use
The PD-L1 IHC (Nivolumab) test is designed to evaluate the expression of the PD-L1 protein (Programmed Death Ligand 1) using immunohistochemistry in patients with squamous cell carcinoma of the head and neck. Positive PD-L1 expression, which is indicated by the presence of membrane staining in tumor cells, is relevant for determining patient eligibility for treatment with nivolumab, an immune checkpoint inhibitor (OPDIVO). This inhibitor works by disrupting PD-1 mediated signaling to restore antitumor immunity, offering a novel therapeutic approach to extend survival and potentially improve the quality of life in patients with advanced squamous cell carcinoma of the head and neck.
Special Instructions
Not provided.
Limitations
The test may not be suitable for tissue samples that have been exposed to equivalent fixation methods other than the prescribed 10% neutral buffered formalin. There is a potential for variability in PD-L1 expression results due to differences in testing protocols or tissue handling. Additionally, the test is only applicable for squamous cell carcinoma of the head and neck and is not intended for use with other tumor types. Samples insufficient in quantity or not properly preserved may be rejected.
Methodology
Immunoassay (IHC)
Biomarkers
PD-L1
Protein
LOINC Codes
- 83055-4 - PD-L1 by 28-8 Tiss Ql ImStn
- 83055-4 - PD-L1 by 28-8 Tiss Ql ImStn
- 83053-9 - Cells.PD-L1/Viab tum NFr Tiss ImStn
- 77202-0 - Laboratory comment Report
- 72486-4 - Lab director name Provider
Result Turnaround Time
5-9 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
One formalin-fixed paraffin embedded (FFPE) tissue block or five unstained positively charged slides
Minimum Volume
Three unstained tissue slides
Container
Tissue block or slide
Collection Instructions
Tissue should be fixed in 10% neutral buffered formalin for no more than 72 hours. Embed in paraffin.
Storage Instructions
Room temperature
Causes for Rejection
Insufficient tissue; tumor other than squamous cell carcinoma of the head and neck
Other tests from different labs that may be relevant