Penicillium chrysogenum
Also known as: Clearance, Creatinine
Use
Renal function test; estimate glomerular filtration rate (GFR); evaluate renal function in small or wasted subjects; follow possible progression of renal disease; adjust dosages of medications in which renal excretion is pivotal (eg, aminoglycosides, methotrexate, cisplatin)
Special Instructions
Not provided.
Limitations
Exercise may cause increased creatinine clearance. The glomerular filtration rate is substantially increased in pregnancy. Ascorbic acid, ketone bodies (acetoacetate), hydantoin, numerous cephalosporins1,2 and glucose may influence creatinine determinations. Trimethoprim, cimetidine, quinine, quinidine, procainamide reduce creatinine excretion. Icteric samples, lipemia, and hemolysis may interfere with determination of creatinine. Since tubular secretion of creatinine is fractionally more important in progressing renal failure, the creatinine clearance overestimates GFR with high serum creatinine levels. While ingestion of meats may cause some increase in creatinine excretion, in practice this seems to make little difference. Intraindividual variation in creatinine clearance is about 15%. Males excrete more creatinine and have slightly higher clearance than females.
Methodology
Colorimetric
Biomarkers
LOINC Codes
- 34555-3
- 6212-5
- 2160-0
- 2161-8
- 2162-6
- 2164-2
- 98979-8
- 6212-5
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Unknown
Volume
Not provided
Minimum Volume
Not provided
Patient Preparation
Avoid cephalosporins. Have patient drink water before the clearance is begun, and continue good hydration throughout the clearance. If possible, drugs should be stopped beforehand.
Causes for Rejection
No blood creatinine drawn; improper labeling