Protein S Deficiency Profile

Clinical Use

Order Test

Use

Confirmation and characterization of protein S (PS) congenital deficiency

Special Instructions

Not provided.

Limitations

The presence of heparin or lupus anticoagulants leads to overestimation of PS. aPC resistance due to factor V Leiden mutation or other causes can falsely lower measured PS activity levels. The test may be affected by various factors such as anticoagulant therapy, liver disease, and hormonal status.

Test Details

Methodology

Immunoassay (Other)

Biomarkers

Protein S, Free

Protein

Concentration / Level

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Protein S, Functional

Protein

Concentration / Level

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

Protein S, Total

Protein

Concentration / Level

Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

87557-5 - Prot S Ag + Prot S Ag.free Pnl PPP IA

Result Codes

27823-4 - Prot S Ag Act/Nor PPP IA
27821-8 - Prot S Free Ag Act/Nor PPP IA
27822-6 - Prot S Act/Nor PPP

Result Turnaround Time

2-3 days

Specimen

Plasma

Volume

1 mL

Minimum Volume

Not provided

Container

Blue-top (sodium citrate) tube

Collection Instructions

Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion. Mix immediately by gentle inversion at least six times. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap. Freeze immediately.