Protein S Deficiency Profile
Use
Confirmation and characterization of protein S (PS) congenital deficiency
Special Instructions
Not provided.
Limitations
The presence of heparin or lupus anticoagulants leads to overestimation of PS. aPC resistance due to factor V Leiden mutation or other causes can falsely lower measured PS activity levels. The test may be affected by various factors such as anticoagulant therapy, liver disease, and hormonal status.
Methodology
Immunoassay (Other)
Biomarkers
Protein S, Free
ProteinProtein S, Functional
ProteinProtein S, Total
Protein
LOINC Codes
- 87557-5 - Prot S Ag + Prot S Ag.free Pnl PPP IA
- 27823-4 - Prot S Ag Act/Nor PPP IA
- 27821-8 - Prot S Free Ag Act/Nor PPP IA
- 27822-6 - Prot S Act/Nor PPP
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
Not provided
Container
Blue-top (sodium citrate) tube
Collection Instructions
Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion. Mix immediately by gentle inversion at least six times. Centrifuge for 10 minutes and carefully remove 2/3 of the plasma using a plastic transfer pipette. Transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap. Freeze immediately.
Storage Instructions
Freeze.
Causes for Rejection
Gross hemolysis; clotted specimen; frozen specimen thawed in transit; improper labeling
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 28 days |
Other tests from different labs that may be relevant