Renin Activity, Plasma, Two Specimens
Use
The Renin Activity, Plasma, Two Specimens test is essential in evaluating patients with suspected disorders of renal or adrenal gland function, hypertension, or electrolyte imbalance. It helps in distinguishing between primary and secondary aldosteronism by measuring the plasma renin activity at baseline and after stimulation. This test involves obtaining two plasma samples: one taken before and one after a stimulatory agent such as a drug or treatment. The comparison between the baseline and the stimulated plasma renin activity values provides critical diagnostic information for appropriate clinical management.
Special Instructions
This panel requires multiple tubes to be drawn at different time points. It is recommended to coordinate with the clinician before performing this test to ensure that it aligns with the patient's current treatment plan. If the patient does not receive any stimulation after the initial draw, this test should not be used. Always refer to the Endocrine Appendix of the LabCorp Directory of Services for further instructions on multiple-specimen testing and ensure adherence to the suggested procedures and protocols.
Limitations
The test has specific specimen requirements; non-frozen, non-separated, or non-EDTA plasma specimens will be rejected. Plasma samples must be collected and processed following strict pre-analytical conditions to ensure the accuracy and reliability of the results. Additionally, external factors such as medications or underlying health conditions may affect the plasma renin activity, necessitating a comprehensive clinical context for interpretation. The test performance characteristics have been determined by Labcorp, but it has not received FDA clearance or approval, which could imply limitations regarding its clinical application or scope.
Methodology
Other
Biomarkers
LOINC Codes
- 17515-8
- 46963-5
- 17515-8
- 25513-3
- 46963-5
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Not provided
Minimum Volume
Not provided
Container
EDTA tube
Collection Instructions
Collect the initial tube as baseline, administer the stimulant, and then collect additional tubes.
Storage Instructions
Specimens must be frozen for transport.
Causes for Rejection
Non-frozen sample received; non-separated sample received; non-EDTA plasma specimen; gross icterus