Salivary Cortisol (Six Specimens), MS (Endocrine Sciences)
Use
The Salivary Cortisol test measures the cortisol level in saliva across six different time points, providing insight into the diurnal pattern of cortisol production. It is used to evaluate adrenal gland function and diagnose disorders such as Cushing's syndrome and Addison's disease. The test is particularly valuable as it reflects free, bioactive hormone levels rather than total serum cortisol, avoiding variability in protein-bound hormone levels.
Special Instructions
The test requires the collection of saliva at specific times, allowing for the assessment of cortisol secretion patterns throughout the day. Specialized salivette collection devices are used for obtaining the specimens, which should be labeled with the patient's name, collection time, and date. These should be submitted simultaneously on the same request form.
Limitations
This test's reliability depends on proper collection procedures at the designated times. It offers a measure of free cortisol, which can be affected by factors such as stress, physiological conditions, and improper handling of specimens. Test results might vary if samples are subjected to repeated freeze/thaw cycles beyond the stable limit stated. This method is not FDA-cleared, implying potential variability in performance characteristics.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 51492-7
- 51493-5
- 51494-3
- 51495-0
- 57692-6
- 57693-4
- 51495-0
- 51494-3
- 51493-5
- 51492-7
- 57692-6
- 57693-4
Result Turnaround Time
7-8 days
Related Documents
For more information, please review the documents below
Specimen
Saliva
Volume
1 mL (each specimen) per time point indicated
Minimum Volume
Not provided
Container
Salivette collection device
Collection Instructions
Label each tube with patient's name, collection time and date. Submit specimens simultaneously on the same request form.
Storage Instructions
Refrigerate.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 5 months |