Sex Hormone-binding Globulin
Also known as: Testosterone-binding Globulin
Use
Levels of SHBG are under the positive control of estrogens and thyroid hormones, and are suppressed by androgens. These influences dynamically control the liver synthesis of this carrier protein. Decreased levels of SHBG are frequently seen in hirsutism, virilization, obese postmenopausal women, and in women with diffuse hair loss. Increased levels may be present in cases of hyperthyroidism, testicular feminization, cirrhosis, male hypogonadism, pregnancy, women using oral contraceptives, and prepubertal children.
Special Instructions
This test may exhibit interference from samples collected from individuals consuming high-dose biotin supplements. Patients should be advised to stop biotin consumption at least 72 hours prior to the sample collection.
Limitations
Erroneous findings may occur with samples from patients treated with monoclonal mouse antibodies or those with extremely high titers of antibodies to streptavidin and ruthenium. The test includes additives to minimize these effects.
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 13967-5
- 13967-5
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.7 mL
Container
Gel-barrier tube (preferred) or red-top tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Room temperature
Causes for Rejection
Citrate plasma specimen; EDTA plasma specimen; improper labeling
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |