SNP Microarray−Oncology (Reveal®)
Also known as: Reveal® Microarray
Use
This test will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.
Special Instructions
Pertinent medical findings should accompany the test request form to ensure comprehensive analysis. Specimens should be sent the same day as collection for optimal results. The test utilizes the Cytoscan® HD Accel platform with a high probe density to ensure detailed analysis.
Limitations
The SNP microarray assay does not detect balanced rearrangements or low-level mosaicism under 10%. It also fails to identify marker chromosomes comprising purely heterochromatin or tetraploidy. The test does not report on CNVs listed in the Database of Genomic Variants due to its limitations. Its performance characteristics have been validated by Labcorp but it has not received FDA clearance or approval.
Methodology
Microarray
Biomarkers
LOINC Codes
- 31208-2
- 62357-9
- 62365-2
- 48672-0
- 11502-2
Result Turnaround Time
10-14 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
2 mL
Container
green-top (heparin) tube (preferred); or yellow-top (ACD) tube or lavender-top (EDTA) tube
Collection Instructions
Using sterile technique, collect 5 mL of blood into a heparin, ACD, or EDTA tube. Invert the tube several times to prevent coagulation. Specimens should be sent the same day as collected.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Suitability of specimen will be determined by the Cytogenetics laboratory upon receipt.