SNP Microarray−Oncology (Reveal®)

Also known as: Reveal® Microarray

Clinical Use

Use

This test will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.

Special Instructions

Not provided.

Limitations

The SNP microarray assay does not detect balanced rearrangements or low-level mosaicism under 10%. It also fails to identify marker chromosomes comprising purely heterochromatin or tetraploidy. The test does not report on CNVs listed in the Database of Genomic Variants due to its limitations. Its performance characteristics have been validated by Labcorp but it has not received FDA clearance or approval.

Test Details

Methodology

Microarray

Biomarkers

Unknown CNV

Copy Number Region

Copy Number Alteration

Copy Number Alteration • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Order Codes

31208-2 - Specimen source
62357-9 - Chrom analy overall interp-Imp

Result Codes

62365-2 - Diagnostic imp Spec-Imp
48672-0 - Clinical cytogeneticist Spec
11502-2 - Laboratory report

Result Turnaround Time

10-14 days

Specimen

Whole Blood

Volume

5 mL

Minimum Volume

2 mL

Container

green-top (heparin) tube (preferred); or yellow-top (ACD) tube or lavender-top (EDTA) tube

Collection Instructions

Using sterile technique, collect 5 mL of blood into a heparin, ACD, or EDTA tube. Invert the tube several times to prevent coagulation. Specimens should be sent the same day as collected.