SNP Microarray−Prenatal (Reveal®)
Also known as: aCGH, Amniotic Fluid Cultures, CGH, CVS Cultures, Prenatal
Use
This test will detect chromosomal imbalances that could be associated with developmental delay/congenital anomalies. It provides detection of possible uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent.
Special Instructions
Chromosome studies are recommended to detect balanced rearrangements not detected by the array. For chromosome analysis, order Chromosome Analysis, Amniotic Fluid [052040] or Chromosome Analysis, Chorionic Villi Biopsy [510988]. Concurrent maternal contamination (MCC) studies are recommended. Include a complete Informed Consent and Prenatal Chromosome SNP Microarray Questionnaire with specimens. A delay notification will be sent if cultures are necessary.
Limitations
This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes containing only heterochromatin, or tetraploidy. Empiric studies have detected whole chromosome mosaicism below certain thresholds, and CNVs from the Database of Genomic Variants are not reported. This test's development and performance characteristics were determined by LabCorp and have not been FDA-cleared or approved.
Methodology
Microarray
Biomarkers
LOINC Codes
- 31208-2
- 48000-4
- 62365-2
- 48672-0
- 11502-2
Result Turnaround Time
10-21 days
Related Documents
For more information, please review the documents below
Specimen
Cultured Cells
Volume
Two T-25 flasks of cultured cells
Minimum Volume
One T-25 flask
Container
T-25 flask
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Upon receipt, suitability of specimen will be determined by the Cytogenetics laboratory.