T-Lymph Markers and NK
Use
This test is used to evaluate the immune status of a patient by measuring T-lymphocyte and natural killer (NK) cell populations in the blood. Such measurements can be critical in assessing immunodeficiency or autoimmune disorders, and in monitoring patients with conditions that affect the immune system, such as HIV infection or after transplantation. The test results can guide clinicians in diagnosing and managing these conditions, ensuring appropriate treatment and follow-up care.
Special Instructions
Not provided.
Limitations
The test is highly dependent on the timing of specimen collection and handling. Specimens must not be refrigerated or frozen, as this can lead to cell degradation and inaccurate results. Hemolysis, clotting, or contamination can also affect the integrity of the specimen and result in test rejection. Furthermore, the test does not differentiate specific subtypes within the T-lymphocyte and NK cell populations beyond the markers measured.
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 8122-4 - CD3 Cells # Bld
- 8124-0 - CD3 Cells NFr Bld
- 24467-3 - CD3+CD4+ Cells # Bld
- 8123-2 - CD3+CD4+ Cells NFr Bld
- 14135-8 - CD3+CD8+ Cells # Bld
- 8101-8 - CD3+CD8+ Cells NFr Bld
- 9728-7 - CD3-CD16+CD56+ Cells # Bld
- 8112-5 - CD3-CD16+CD56+ Cells NFr Bld
- 6690-2 - WBC # Bld Auto
- 789-8 - RBC # Bld Auto
- 718-7 - Hgb Bld-mCnc
- 4544-3 - Hct VFr Bld Auto
- 787-2 - MCV RBC Auto
- 785-6 - MCH RBC Qn Auto
- 786-4 - MCHC RBC Auto-EntMCnc
- 788-0 - Erythrocyte DistWidth Bld Auto
- 777-3 - Platelet # Bld Auto
- 770-8 - Neutrophils NFr Bld Auto
- 736-9 - Lymphocytes NFr Bld Auto
- 5905-5 - Monocytes NFr Bld Auto
- 713-8 - Eosinophil NFr Bld Auto
- 706-2 - Basophils NFr Bld Auto
- 75652-8 - Imm Lymphs Bld Ql
- 751-8 - Neutrophils # Bld Auto
- 731-0 - Lymphocytes # Bld Auto
- 742-7 - Monocytes # Bld Auto
- 711-2 - Eosinophil # Bld Auto
- 704-7 - Basophils # Bld Auto
- 71695-1 - Imm Granulocytes NFr Bld Auto
- 53115-2 - Imm Granulocytes # Bld Auto
- 58413-6 - nRBC Bld Auto-Rto
- 18314-5 - Morphology Bld-Imp
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
Fill tube(s) to capacity.
Minimum Volume
Not provided
Container
Lavender-top (EDTA) tube and yellow-top (ACD-A) or (ACD-B) tube
Collection Instructions
Invert tube 8 to 10 times immediately after collection. To preserve cellular viability, collect specimen so it will arrive in the laboratory within 48 hours of collection. Indicate date and time of venipuncture on the tube(s) and on the test request form.
Storage Instructions
Maintain specimen at room temperature. Do not freeze or refrigerate.
Causes for Rejection
Specimen refrigerated or frozen; clotted specimen; hemolysis; contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Yellow-top (ACD-A) or (ACD-B) tube: 2 days; Lavender-top (EDTA) tube: 1 day |
| Refrigerated | Unstable |
| Frozen | Unstable |
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